PROPARGYLAMINE CAS#2450-71-7
Versatile Chemical Building Block: Propargylamine is an important alkynyl amine compound that serves as a valuable intermediate in organic synthesis and chemical research.
Unique Reactive Functional Group: Containing both alkyne and amino groups, Propargylamine offers excellent chemical reactivity for the construction of various functional molecules.
Wide Biological Research Applications: It can interact with important biological targets, including aldehyde dehydrogenase, diamine oxidase, monoamine oxidase, and glycine cleavage-related enzymes.
Flexible Formulation and Processing Characteristics: Propargylamine is available as a free-base liquid and a water-soluble hydrochloride form, providing adaptability for different research and industrial applications.
Product Description of Propargylamine CAS#2450-71-7
Propargylamine (CAS#2450-71-7), also known as 3-amino-1-propyne, is an alkynyl amine compound with the chemical structure HCCCH₂–NH₂ and a molecular weight of 55.08 g/mol for the free base. It is a toxic liquid with a boiling point of 83°C.
Its hydrochloride salt is water-soluble and has a melting point of 179–182°C. Propargylamine is associated with various biological targets, including aldehyde dehydrogenase, diamine oxidase (copper-containing amine oxidase), glycine cleavage complex (glycine synthase), and monoamine oxidase (flavin-containing amine oxidase).
PROPARGYLAMINE Chemical Properties
| Boiling point | 84 °C |
| density | 0.86 |
| refractive index | n20/D 1.449(lit.) |
| Fp | 39 °F |
| storage temp. | 2-8°C |
| solubility | soluble in Chloroform, Ethyl Acetate |
| form | Liquid |
| pka | 7.89±0.29(Predicted) |
| color | Clear colorless to yellow |
| Appearance | Colorless volatile liquid |
| Water Solubility | miscible |
| Sensitive | Air Sensitive |
| BRN | 773681 |
| Dielectric constant | 6.65 |
| InChI | 1S/C3H5N/c1-2-3-4/h1H,3-4H2 |
| InChIKey | JKANAVGODYYCQF-UHFFFAOYSA-N |
| SMILES | NCC#C |
| CAS DataBase Reference | 2450-71-7(CAS DataBase Reference) |
| NIST Chemistry Reference | Propargylamine(2450-71-7) |
| EPA Substance Registry System | 2-Propyn-1-amine (2450-71-7) |
| Hazard Codes | F,T |
| Risk Statements | 11-22-24-34 |
| Safety Statements | 16-26-33-36/37/39-45-28A |
| RIDADR | UN 1992 3/PG 2 |
| WGK Germany | 3 |
| RTECS | UK5250000 |
| F | 3-8-10-34 |
| TSCA | TSCA listed |
| HazardClass | 3.1 |
| PackingGroup | II |
| HS Code | 29211990 |
| Storage Class | 3 - Flammable liquids |
| Hazard Classifications | Acute Tox. 2 Dermal |
| Acute Tox. 4 Oral | |
| Eye Dam. 1 | |
| Flam. Liq. 2 | |
| Skin Corr. 1B |
Product Application of Propargylamine CAS#2450-71-7
Propargylamine is utilized in the synthesis of chiral fluorescent macrocycles through the 1,3-dipolar cycloaddition reaction between propargyl amides derived from carbohydrate-linked amino acids and 9,10-bis(azidomethyl)anthracene.
It also serves as an important intermediate in the production and development of pharmaceutical compounds.
