Tetrahydrofuran CAS#109-99-9
Excellent Solvent Performance: A highly polar ether solvent with strong solvating ability, widely used as a medium-polar solvent in chemical reactions and extraction processes.
Broad Solubility and Compatibility: Known as a “universal solvent” due to its excellent solubility in various organic solvents, including water, ethanol, ether, acetone, and benzene.
Low Toxicity and Favorable Handling Properties: Features low toxicity, low boiling point, and good fluidity, making it suitable for a wide range of industrial applications.
High Purity and Storage Stability: Industrial-grade THF typically contains antioxidant BHT to inhibit peroxide formation, with controlled moisture content (≤0.2%) for reliable performance.
Parameters
| Melting point | -108°C |
| Boiling point | 66 °C |
| density | 0.887 g/mL at 20 °C |
| vapor density | 2.5 (vs air) |
| vapor pressure | <0.01 mm Hg ( 25 °C) |
| refractive index | n20/D 1.465 |
| Fp | >230 °F |
| storage temp. | Store at +5°C to +30°C. |
| solubility | water: soluble |
| form | Liquid |
| Specific Gravity | 0.89 |
| color | <10(APHA) |
| Relative polarity | 0.207 |
| PH | 7-8 (200g/l, H2O, 20℃) |
| Odor | Ethereal, detectable at 2 to 50 ppm |
| PH Range | 7 |
| explosive limit | 1.5-12.4%(V) |
| Water Solubility | miscible |
| FreezingPoint | -108℃ |
| Sensitive | Air Sensitive & Hygroscopic |
| λmax | λ: 245 nm Amax: ≤0.26 |
| λ: 275 nm Amax: ≤0.046 | |
| λ: 315 μm Amax: ≤0.0044 | |
| Merck | 149211 |
| BRN | 102391 |
| Henry's Law Constant | 1.54 (static headspace-GC, Welke et al., 1998) |
| Exposure limits | TLV-TWA 200 ppm (590 mg/m3) (ACGIH, MSHA, and OSHA); STEL 250 ppm (ACGIH); IDLH 20,000 ppm (NIOSH). |
| Dielectric constant | 7.58 |
| Dielectric constant | 11.6（-70℃） |
| Stability: | Stable. Incompatible with halogens, strong oxidizing agents, strong reducing agents, strong bases, oxygen. May generate explosive peroxides in storage if in contact with air. Highly flammable. Store at room temperature under nitrogen. Hazardous polymerisation may occur. Light sensitive. May contain 2,6-di-tertbutyl-4-methylphenol (BHT) as a s |
| InChIKey | WYURNTSHIVDZCO-UHFFFAOYSA-N |
| LogP | 0.45 at 25℃ |
| Surface tension | 27.31mN/m at 293.15K |
| CAS DataBase Reference | 109-99-9(CAS DataBase Reference) |
| NIST Chemistry Reference | Furan, tetrahydro-(109-99-9) |
| IARC | 2B (Vol. 119) 2019 |
| EPA Substance Registry System | Tetrahydrofuran (109-99-9) |
| Absorption | ≤0.0044 at 315nm |
| ≤0.005 at 350nm | |
| ≤0.005 at 400nm | |
| ≤0.02 at 300nm | |
| ≤0.046 at 275nm | |
| ≤0.18 at 250nm | |
| ≤0.26 at 245nm | |
| ≤1.0 at 212nm |
Safety Information
| Hazard Codes | Xi,F,Xn |
| Risk Statements | 36/37/38-36/37-19-11-40 |
| Safety Statements | 26-36-33-29-16-46-37-13 |
| RIDADR | UN 2924 3/PG 2 |
| OEB | A |
| OEL | TWA: 200 ppm (590 mg/m3), STEL: 250 ppm (735 mg/m3) |
| WGK Germany | 1 |
| RTECS | MD0916000 |
| F | 37917 |
| Autoignition Temperature | 610 °F |
| TSCA | Yes |
| HazardClass | 3 |
| PackingGroup | II |
| HS Code | 29321100 |
| Hazardous Substances Data | 109-99-9(Hazardous Substances Data) |
| Toxicity | LD50 oral (rat) 2880 mg/kg |
| LC50 inhal (rat) 21,000 ppm (3 h) | |
| PEL (OSHA) 200 ppm (590 mg/m3) | |
| TLV-TWA (ACGIH) 200 ppm (590 mg/m3) | |
| STEL (ACGIH) 250 ppm (737 mg/m3) | |
| IDLA | 2,000 ppm [10% LEL] |
Product Application of Tetrahydrofuran CAS#109-99-9
Tetrahydrofuran (THF) is widely used as an effective solvent in various chemical processes. It also serves as an important raw material and intermediate for organic synthesis, supporting the production of a wide range of chemical compounds and industrial products.
