Dimethyl fumarate CAS#624-49-7
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Established Multiple Sclerosis Treatment – Used for the treatment of adults with relapsing forms of multiple sclerosis.
Immunomodulatory Properties – Functions as an immunomodulator, supporting its therapeutic applications in immune-related conditions.
Antipsoriatic Activity – Exhibits antipsoriatic properties, providing additional pharmaceutical applications.
Well-Defined Chemical Structure – An enoate ester, methyl ester, and diester derived from fumaric acid and methanol, offering a clearly defined chemical profile.
Dimethyl Fumarate CAS#624-49-7
Dimethyl fumarate is an enoate ester formed through the formal condensation of both carboxyl groups of fumaric acid with methanol. It is used for the treatment of adults with relapsing forms of multiple sclerosis and functions as an immunomodulator and antipsoriatic agent.
Dimethyl fumarate is classified as an enoate ester, methyl ester, and diester. Structurally, it is functionally related to methanol and fumaric acid.
Dimethyl fumarate Chemical Properties
| Melting point | 102-106 °C (lit.) |
| Boiling point | 192-193 °C (lit.) |
| density | 1,37 g/cm3 |
| vapor pressure | 5 hPa (25 °C) |
| refractive index | 1.4062 (estimate) |
| Fp | 192-193°C |
| storage temp. | Store below +30°C. |
| solubility | 1.6g/l |
| form | Liquid |
| color | Clear colorless to faintly yellow |
| PH | 4.0-6.0 (10g/l, H2O, 20℃)suspension |
| Water Solubility | Soluble in water (1.6 mg/ml at 20°C), methanol (30-36 mg/ml), ethanol (10 mg/ml at 25°C), DMSO (29 mg/ml at 25°C), and DMF (~12 mg/ml). |
| Merck | 144287 |
| BRN | 774590 |
| Stability: | Stable. Incompatible with acids, bases, oxidizing agents, reducing agents. |
| InChI | 1S/C6H8O4/c1-9-5(7)3-4-6(8)10-2/h3-4H,1-2H3/b4-3+ |
| InChIKey | LDCRTTXIJACKKU-ONEGZZNKSA-N |
| SMILES | [H]\C(=C(\[H])C(=O)OC)C(=O)OC |
| CAS DataBase Reference | 624-49-7(CAS DataBase Reference) |
| NIST Chemistry Reference | 2-Butenedioic acid (E)-, dimethyl ester(624-49-7) |
| EPA Substance Registry System | 2-Butenedioic acid (2E)-, 1,4-dimethyl ester (624-49-7) |
| Hazard Codes | Xn |
| Risk Statements | 21-38-41-43-36/37/38-36/38 |
| Safety Statements | 26-36/37/39-36/37 |
| RIDADR | UN 3077 9 / PGIII |
| WGK Germany | 1 |
| RTECS | EM6125000 |
| TSCA | TSCA listed |
| HazardClass | 9 |
| HS Code | 29171990 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Dermal |
| Aquatic Chronic 2 | |
| Skin Irrit. 2 | |
| Skin Sens. 1 | |
| STOT SE 3 | |
| Hazardous Substances Data | 624-49-7(Hazardous Substances Data) |
| Toxicity | LD50 orally in Rabbit: 2240 mg/kg LD50 dermal Rabbit 1250 mg/kg |
Product Application of Dimethyl Fumarate CAS#624-49-7
Dimethyl fumarate acts as an immunomodulator and is also used in cycloaddition reactions involving ylides, benzenes, and amino acids.
In addition, dimethyl fumarate is used as a preservative for food grains, tobacco, leather, and other materials.
