L-Arginine L-Glutamate CAS#4320-30-3
L-Arginine L-glutamate can be prepared by mixing L-arginine with L-glutamic acid in water and crystallizing the resulting salt through the addition of a polar, water-miscible organic solvent.
For example, 17.2 g of L-arginine and 14.5 g of L-glutamic acid were dissolved in 155 g of water to form a clear, homogeneous solution with a pH of 5.3. The solution was then filtered, and the filtrate was concentrated under reduced pressure at 50°C until the solids content reached approximately 45%.
A total of 220 g of absolute methanol was added to the concentrated salt solution, and the mixture was cooled to 5°C for one hour. The resulting solid salt was separated by filtration and washed with absolute methanol. After preliminary air drying, the salt was further dried in a vacuum oven at 60°C for 3 hours.
The resulting L-arginine L-glutamate weighed 30 g, corresponding to 94.6% of the theoretically possible yield based on the amounts of L-arginine and L-glutamic acid used. The product melted at 193–194.5°C with decomposition.
L-Arginine L-glutamate Chemical Properties
| Melting point | >185°C (dec.) |
| storage temp. | −20°C |
| solubility | Aqueous Acid (Sparingly), Water (Slightly) |
| form | Solid |
| color | White to Off-White |
| Odor | odorless |
| Cosmetics Ingredients Functions | SKIN CONDITIONING |
| HAIR CONDITIONING | |
| LogP | -1.287 (est) |
| CAS DataBase Reference | 4320-30-3(CAS DataBase Reference) |
| EPA Substance Registry System | L-Glutamic acid compd. with L-Arginine (1:1) (4320-30-3) |
| WGK Germany | 3 |
| TSCA | TSCA listed |
Product Application of L-Arginine L-Glutamate CAS#4320-30-3
L-Arginine L-glutamate is used in the preparation of arginine glutamate solutions for the treatment of radiation-induced skin ulcers in guinea pigs.
