Kojic Acid#501-30-4
Identified by CAS#501-30-4, kojic acid is a tyrosinase inhibitor synthesized by fungi like Aspergillus oryzae. Its mechanism involves chelating copper within tyrosinase, reducing melanin synthesis and imparting skin-lightening properties. Commonly utilized in cosmetic products—such as regular and bleaching creams—as a whitening agent, it also functions as a therapeutic agent to mitigate pigmentation issues.
Kojic acid Chemical Properties
Melting point | 152-155 °C (lit.) |
Boiling point | 179.65°C (rough estimate) |
density | 1.1712 (rough estimate) |
refractive index | 1.4434 (estimate) |
storage temp. | Store below +30°C. |
solubility | DMSO (Slightly), Methanol (Slightly, Sonicated) |
form | Crystalline Powder |
pka | 7.9(at 25℃) |
color | White to beige-brown |
Water Solubility | SOLUBLE |
λmax | 269nm(CHCl3)(lit.) |
Merck | 14,5317 |
BRN | 120895 |
Stability: | Stable. Combustible. Incompatible with strong oxidizing agents. |
LogP | -0.640 |
CAS DataBase Reference | 501-30-4(CAS DataBase Reference) |
NIST Chemistry Reference | 5-Hydroxy-2-(hydroxymethyl)-4h-pyran-4-one(501-30-4) |
IARC | 3 (Vol. 79) 2001 |
EPA Substance Registry System | Kojic acid (501-30-4) |
Safety Information
Hazard Codes | Xn |
Risk Statements | 40-68 |
Safety Statements | 22-24/25-36/37-36 |
WGK Germany | 3 |
RTECS | UQ0875000 |
HS Code | 29329995 |
Hazardous Substances Data | 501-30-4(Hazardous Substances Data) |
Product Application of Kojic acid#501-30-4
Kojic acid (CAS#501-30-4) functions as a skin-lightening agent with antioxidant properties. As a tyrosinase inhibitor, it is less effective than licorice extract but still valuable. When combined with allantoin and other suitable ingredients in sunscreen formulations, it helps suppress UV-induced erythema and promotes wound healing. However, kojic acid may cause skin sensitization and irritation.
